Chemotherapy was potentiated by E7449 and one agent had sizeable antitumor activity in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, very likely by means of TNKS inhibition. Per this risk, E7449 stabilized axin and TNKS proteins resulting in β-catenin de-stabilization and substantially altered expression of https://gustaveu963bti0.blogs100.com/profile