Background: Alveolar bone defects in children still have a high incidence. Conventional bone graft technique that has been used as a defect therapy is still not effective. so new techniques with tissue engineering approach are needed. Bone Morphogenetic Protein 4 (BMP4) as one of the indicators of osteogenic differentiation has not been widely studied. https://www.bekindtopets.com/hot-find-Synovex-One-Grass-Extended-Release-Implant-10-Dose-special-find/