There is a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to minimize afferent suffering transmission and generate analgesia. Hence, medicines like clonidine that goal alpha-2 receptors can impact the transmission of agony. Applies to clonidine: oral pill, oral pill https://www.proleviate.com/post/the-new-pain-killer-conolidine